Preliminary results of the epilepsy trial

EUGENE, OREGON, US, 12 April 2017 - Electrical Geodesics, Inc. ("EGI" or the "Company"), a leading neurodiagnostic medical technology company, today provides preliminary results of case studies from the first three patients treated in its safety and feasibility trial for suppressing focal epilepsy with Geodesic Transcranial Electrical Neuromodulation (GTEN).

The patients in this trial at the University of Washington Harborview Hospital in Seattle suffer from focal epilepsy (ie epilepsy associated with a specific region of the brain) that is not controlled by medication. The epileptic discharges reflect the abnormal activity of the brain that is often associated with generating seizures. Each of the three patients has demonstrated a statistically significant suppression of epileptic discharges immediately following treatment, where statistical significance is measured by the change in the epileptic discharge rate (before versus after treatment) across the five treatment days.

GTEN represents an advance in targeting brain regions for electrical neuromodulation with a dense electrode array (256 channels) distributed over the head surface, and with high performance computing applied to model the distribution of electrical current in each patient's head tissues. EGI's proprietary technology allows the use of the patient's dense array electroencephalography ("dEEG") to guide the targeting of the therapeutic pulses of electric current. GTEN is currently sold for research use only and will require clearance from a regulatory body such as the FDA in order to be sold for treatment of each specific disorder, including epilepsy.

A preliminary report on the epilepsy trial results will be presented at the Brain Stimulation and Imaging Symposium June 23-24 at the Organization for Human Brain Mapping meetings in Vancouver, BC, Canada.

EGI would need to secure additional funding in order to advance the clinical trial through to a pivotal study at the current centre within the University of Washington, and to extend the trial to a new site at Huashan Hospital of the Fudan University Shanghai Medical College in Shanghai, China. Subject to funding being secured, the goal would be to complete the recruitment of the planned 20 patients in the feasibility study by year end 2017, report the results to FDA, and plan for a pivotal trial commencing in 2018.

Dr. Don Tucker, CEO of EGI, commented: "Although we have as yet only assessed a small number of patients, these improvements immediately following treatment support our hypothesis that accurate targeting of epileptic regions of the brain with our GTEN technology will allow reduction of cortical excitability and thus suppression of epileptic discharges, at least acutely. For the pivotal trial, we need to understand how lasting the effect is, and whether it will result in suppression of seizures."

Dr. Mark Holmes, epileptologist and Principal Investigator of the University of Washington trial, added, "These are exciting results with very difficult patients. Even a temporary suppression of seizure activity could be clinically significant for the 35% of patients who continue to suffer from seizures despite taking multiple anticonvulsant medications."

For more information contact: EGI – Ann Bunnenberg, President, +1 541 687 7962

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Electrical Geodesics, Inc. in Summary
Founded in 1992, EGI designs, develops and commercialises a range of non-invasive neurodiagnostic and neuromodulation products used to monitor, interpret and modulate brain activity, based on its proprietary dense array electroencephalography ("dEEG") platform technology. The Company's technology uses up to 256 sensors, providing much higher resolution brain activity data compared to conventional 8 or 16 channel EEG and is used in medical, clinical and research settings in a diverse range of applications including important areas such as the diagnosis and monitoring of epilepsy, neurosurgical planning, sleep assessment, and many others.

EGI's dEEG systems, available in the GES 300 and now the GES 400 lines, capitalise on the Company's unique Hydrocel Geodesic Sensor Net which allows faster, easier, and more convenient placement of many EEG sensors in an even distribution over the entire scalp, providing more accurate and precise diagnosis and measurement. EGI's technology is now widely used in neuroscience research laboratories and is becoming more commonly used in clinics, care centers, and hospitals around the world. Data is measured and visualised using EGI's proprietary amplifier technology and software, providing a complete, advanced, high-resolution EEG platform. The Company's products are compatible with multiple diagnostic and imaging technologies, including magnetic resonance (MR) imaging, functional MRI (fMRI), and magneto-encephalography (MEG).

See our website: www.egi.com

Glossary
EEG Electroencephalography
dEEG Dense-array EEG
GTEN Geodesic transcranial electrical neuromodulation
GS3 GeoSource 3
MRI Magnetic resonance imaging
fMRI functional MRI
PET Positron emission tomography
MEG Magneto enecephalography
NIRS Near-infra-red spectroscopy
TES Trans-cranial electrical stimulation
TMS Trans-cranial magnetic stimulation
rTMS repetitive Trans-cranial magnetic stimulation

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